BDBM50329330 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl-1H-imidazole-4-carboxylate::CHEMBL1270605

SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1cnc[nH]1

InChI Key InChIKey=WXPWXVFSLOPCOW-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50329330   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50329330(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataKi:  870nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 catalytic site assessed as 15-HPETE formation by Michaelis-Menten equation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50329330(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 catalytic site assessed as 15-HPETE formation by Michaelis-Menten equation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50329330(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataKi:  8.10E+3nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 allosteric site assessed as 15-HPETE formation by Michaelis-Menten equation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed