BDBM50329316 (R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid 5-carbamoyl-adamantan-2-yl ester::CHEMBL1270001

SMILES NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Nc1ccc(cn1)C#N)C(C3)C2

InChI Key

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50329316   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 3betaHSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17betaHSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 8.65E+3nMAssay Description:Inhibition of 11betaHSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed