BDBM50329203 5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)nicotinamide::CHEMBL1270208

SMILES FC(F)(F)COc1ncccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1

InChI Key InChIKey=ZSKFKDOCPJGONT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50329203   

TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KCNQ2/Q3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human NaV1.5 by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 28nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CaV2.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 87nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human ERG by Isotopic flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed