BDBM50329179 2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)-N-benzyl-N-isopropylacetamide::CHEMBL1269258

SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O

InChI Key InChIKey=UBNMGTSDHSQBEL-UHFFFAOYSA-N

Data  8 KI  35 IC50  14 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 50329179   

TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 269nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R W6.48A mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R L7.39H mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I-CCK] from human CCK1R N2.61T mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 37nMAssay Description:Displacement of [125I-CCK] from human CCK1R T3.28V, T3.29S mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 43nMAssay Description:Displacement of [125I-CCK] from human CCK1R I6.51V, F6.52Y mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 676nMAssay Description:Displacement of [125I-CCK] from human CCK1R L7.39H mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I-BDZ-2] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I-BDZ-2] from human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I-CCK] from human CCK2R T2.61N mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 209nMAssay Description:Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I-CCK] from human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R M3.32A mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 794nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R V3.36A mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R I6.51V, F6.52Y mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 166nMAssay Description:Displacement of [125I-CCK] from human CCK1R M3.32A mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 17nMAssay Description:Displacement of [125I-CCK] from human CCK1R V3.36A mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 42nMAssay Description:Displacement of [125I-CCK] from human CCK1R W6.48A mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 3.10nMAssay Description:Agonist activity at human CCK1R V3.36A mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 100nMAssay Description:Agonist activity at human CCK1R W6.48A mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 77nMAssay Description:Displacement of [125I]-BDZ-1 from wild-type rat CCK1R expressed in COS cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]-BDZ-1 from rat CCK1R Ala-317,321,325 non dimerizing mutant expressed in COS cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 31.7nMAssay Description:Displacement of [125I]CCK8 from human CCK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  315nMAssay Description:Agonist activity at human CCK1 receptor expressed in CHO cells assessed as induction of calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 12.2nMAssay Description:Displacement of [125I]CCK8 from rat CCK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  446nMAssay Description:Agonist activity at rat CCK1 receptor expressed in CHO cells assessed as induction of calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 23.6nMAssay Description:Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  123nMAssay Description:Agonist activity at human CCK1 receptor assessed as increase in CCK8-induced calcium release incubated in dark for 30 mins followed by light incubati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 141nMAssay Description:Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 275nMAssay Description:Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 617nMAssay Description:Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 141nMAssay Description:Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 22.4nMAssay Description:Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  977nMAssay Description:Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  1.00E+3nMAssay Description:Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 634nMAssay Description:Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  1.51nMAssay Description:Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  0.525nMAssay Description:Agonist activity at human CCK1R N2.61T mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human CCK1R T3.28V, T3.29S mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human CCK1R I6.51V, F6.52Y mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human CCK2R T2.61N mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human CCK2R V3.28T, S3.29T mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 4.5nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R T3.28V, T3.29S mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  282nMAssay Description:Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataIC50: 93nMAssay Description:Displacement of [125I-BDZ-1] from human CCK1R N2.61T mutant expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50329179(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
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