BDBM50328504 (S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrodibenzo[b,f]thiepin-2-yl)methyl)acetamide::CHEMBL1259174

SMILES CN1CCN(CC1)[C@H]1Cc2ccccc2Sc2ccc(CNC(C)=O)cc12

InChI Key InChIKey=YBCFDDCJLZVHPZ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50328504   

TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328504((S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrod...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]prozosin from bovine cloned Alpha-1A receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328504((S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrod...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]prozosin from hamster cloned alpha-1b receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328504((S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrod...)
Affinity DataKi:  0.980nMAssay Description:Displacement of [3H]prozosin from rat cloned alpha1d receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328504((S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrod...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328504((S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrod...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328504((S)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrod...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed