BDBM50328295 4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)-2-hydroxypropoxy)phenol::CHEMBL1257916

SMILES OC(CNC1CCN(CC1)c1ncnc2scc(-c3ccc(F)cc3)c12)COc1ccc(O)cc1

InChI Key InChIKey=JJOCETMXNTXDBF-UHFFFAOYSA-N

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50328295   

TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328295(4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-...)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328295(4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as inhibition of isoproterenol-induced cyclic AMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328295(4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328295(4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-...)
Affinity DataKi:  75nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328295(4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-...)
Affinity DataKi:  175nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328295(4-(3-(1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-...)
Affinity DataKi:  600nMAssay Description:Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed