BDBM50327976 CHEMBL215476::N-benzyl-N-(2-((4-cyanophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)pyridine-2-sulfonamide::pyridine-2-sulfonicacidbenzyl-{2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-ylmethyl)amino]ethyl}amide

SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N

InChI Key InChIKey=HAVQUHAYFMIFJN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327976   

LigandPNGBDBM50327976(N-benzyl-N-(2-((4-cyanophenyl)((1-methyl-1H-imidaz...)
Affinity DataIC50: 90nMAssay Description:Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327976(N-benzyl-N-(2-((4-cyanophenyl)((1-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Rap1A geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327976(N-benzyl-N-(2-((4-cyanophenyl)((1-methyl-1H-imidaz...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327976(N-benzyl-N-(2-((4-cyanophenyl)((1-methyl-1H-imidaz...)
Affinity DataIC50: 820nMAssay Description:Inhibition of human geranylgeranyltransferase-1 assessed as incorporation of [3H]GGPP into H-Ras-CVLLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed