BDBM50327965 CHEMBL1256417::cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenyl)-5,7-dimethylbenzo[d]oxazol-2-amine

SMILES CN1CCN(CC1)[C@H]1CC[C@H](CC1)n1nc(-c2ccc(Nc3nc4cc(C)cc(C)c4o3)c(F)c2)c2c(N)ncnc12

InChI Key InChIKey=BCCBBFDXEPUOFF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327965   

TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327965(cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyc...)
Affinity DataIC50: 160nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327965(cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyc...)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327965(cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyc...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Homo sapiens (human) recombinant C-terminal GST-tagged IGF1R expressed in baculovirus infected Sf21 cells by homogeneous time-resolved ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327965(cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyc...)
Affinity DataIC50: 158nMAssay Description:Inhibition of Homo sapiens (human) recombinant C-terminal GST-tagged IGF1R expressed in baculovirus infected Sf21 cells by homogeneous time-resolved ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article