BDBM50326959 1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methyl-2-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-ol::CHEMBL1254080

SMILES COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1

InChI Key InChIKey=BFWRCRIDNKRGTD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50326959   

TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326959(1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...)
Affinity DataIC50: 12nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326959(1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...)
Affinity DataEC50:  69nMAssay Description:Transactivation activity at glucocorticoid receptor in HFF assessed as induction of aromatase activity after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326959(1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...)
Affinity DataIC50: 480nMAssay Description:Binding affinity to mineralocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326959(1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...)
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326959(1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...)
Affinity DataIC50: 40nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed