BDBM50326662 10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one::CHEMBL607405

SMILES CO[C@]12CCC(=O)[C@@H]3Oc4c5c(C[C@H]1N(C)CC[C@@]235)ccc4O

InChI Key InChIKey=FCIDDJPMOSRHJG-UHFFFAOYSA-N

Data  12 KI  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50326662   

TargetMu-type opioid receptor(Guinea pig)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataIC50: 2nMAssay Description:In vitro agonistic activity against opioid receptor mu of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataEC50:  116nMAssay Description:Agonist activity at human KOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human DOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes incubated for 60 mins scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataIC50: 30.5nMAssay Description:In vitro agonistic activity against opioid receptor delta of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes incubated for 45 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H][Ile5,6]deltorphin II from delta opioid receptor in rat brain membranes incubated for 45 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]-diprenorphine from recombinant human DOR expressed in CHO cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea-pig brain membranes incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  10.2nMAssay Description:Inhibition of [3H]U-69593 binding to opioid receptor kappa from guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  43.6nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50326662(10-hydroxy-17-methoxy-4-methyl-(13R,17S)-12-oxa-4-...)
Affinity DataKi:  2.66E+3nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed