BDBM50326514 (E)-4-(Methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxy-quinoline-6-yl]amide::CHEMBL1243255

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNC

InChI Key InChIKey=WOFSPKZUAHWIEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50326514   

TargetEpidermal growth factor receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50326514((E)-4-(Methylamino)-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50: 5.35nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50326514((E)-4-(Methylamino)-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed