BDBM50326374 (S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide::CHEMBL1243374

SMILES O=C(CNC(=O)c1cccc2ccccc12)N1CCC[C@H]1C#N

InChI Key InChIKey=HSIDTMLTVRFYGR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50326374   

TargetDipeptidyl peptidase 2(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Mouse)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 670nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant FAP expressed in Hi5 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DPP8 expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DPP9 expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DPP2 expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50326374((S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-na...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DPP4 expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed