BDBM50326287 2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)ethyl)pyridine::CHEMBL1243335

SMILES CC(C)(C)c1ccc(SCC(c2cnc[nH]2)c2ccccn2)cc1

InChI Key InChIKey=UNQMLUWBMWGIRY-UHFFFAOYSA-N

Data  4 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50326287   

TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50: 270nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50: 820nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  840nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed