BDBM50326202 CHEMBL1243042::N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-phenoxybenzamide

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Oc2ccccc2)cc1C

InChI Key InChIKey=OXCBIRNMZPQWLB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50326202   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326202(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 56nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326202(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed