BDBM50326009 5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-one::CHEMBL1240928

SMILES Cc1occ2Cc3c(O)ccc(O)c3C(=O)c12

InChI Key InChIKey=TZUYDLKHNQUNKS-UHFFFAOYSA-N

Data  1 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50326009   

TargetMyosin light chain kinase, smooth muscle(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50326009(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MYLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetELAV-like protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50326009(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Affinity DataKd:  14nMAssay Description:Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein interaction with TMR-labeled A/U-rich element of TNFalpha by confocal fluctuation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetELAV-like protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50326009(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Affinity DataKd:  0.100nMAssay Description:Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein dimerization with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetELAV-like protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50326009(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Affinity DataKd:  230nMAssay Description:Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein interaction with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetELAV-like protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50326009(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Affinity DataKd:  420nMAssay Description:Binding affinity recombinant HuR RRM1/RRM2 domain by confocal fluctuation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetELAV-like protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50326009(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Affinity DataKd:  0.100nMAssay Description:Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein dimerization with TMR-labeled A/U-rich element of TNFalpha by confocal fluctuation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed