BDBM50325744 CHEMBL1223683::N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)quinolin-2-amine

SMILES Clc1cccc(N2CCN(CCCCNc3ccc4ccccc4n3)CC2)c1Cl

InChI Key InChIKey=KFOXMHFDNRTETJ-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50325744   

TargetD(2) dopamine receptor(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]spiperone from human dopamine D2S receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  10nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]prazosin from human adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at H4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50325744(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)q...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details Article
PubMed