BDBM50324477 Benzylsulfonyl-D-cyclohexylalanyl-proline-(4-amidinobenzyl)-amide Trifluoroacetate::CHEMBL1215085::CHEMBL1229261

SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CCCCC2)NS(=O)(=O)Cc2ccccc2)cc1

InChI Key InChIKey=DJNNZKJZFCRFRX-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50324477   

TargetProthrombin(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324477(CHEMBL1215085 | CHEMBL1229261 | Benzylsulfonyl-D-c...)
Affinity DataKi:  0.102nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324477(CHEMBL1215085 | CHEMBL1229261 | Benzylsulfonyl-D-c...)
Affinity DataKi:  0.119nMAssay Description:Inhibition of human thrombin using Tos-Gly-Pro-Arg-AMC as substrate after 600 secs by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTransmembrane protease serine 11D(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324477(CHEMBL1215085 | CHEMBL1229261 | Benzylsulfonyl-D-c...)
Affinity DataKi:  108nMAssay Description:Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324477(CHEMBL1215085 | CHEMBL1229261 | Benzylsulfonyl-D-c...)
Affinity DataKi:  290nMAssay Description:Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324477(CHEMBL1215085 | CHEMBL1229261 | Benzylsulfonyl-D-c...)
Affinity DataKi:  460nMAssay Description:Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324477(CHEMBL1215085 | CHEMBL1229261 | Benzylsulfonyl-D-c...)
Affinity DataKi:  770nMAssay Description:Inhibition of human recombinant matriptase catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed