BDBM50324316 CHEMBL1214929::N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-1,2-diamine

SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1

InChI Key InChIKey=OBRQLJITIRIMLQ-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50324316   

TargetProtein kinase C alpha type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 900nMAssay Description:Inhibition of PKCalpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 321nMAssay Description:Inhibition of PKD1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 5.42E+3nMAssay Description:Inhibition of PKD1 assessed as HDAC5 neuclear exportMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PKCdelta by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 859nMAssay Description:Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed