BDBM50323919 4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenoxy)-N-methylpicolinamide::CHEMBL1213974

SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)cc2)ccn1

InChI Key InChIKey=HOHLGEPKIHZUGO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323919   

TargetTyrosine-protein kinase ABL1(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50323919(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ur...)
Affinity DataIC50: 62.6nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50323919(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ur...)
Affinity DataIC50: 237nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50323919(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ur...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed