BDBM50323918 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)urea::CHEMBL1213973

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1)C(C)(C)C

InChI Key InChIKey=BBZXKDAPACZAMH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323918   

TargetTyrosine-protein kinase ABL1(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50323918(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-me...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50323918(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-me...)
Affinity DataIC50: 414nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50323918(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-me...)
Affinity DataIC50: 189nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed