BDBM50323733 1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE::1-isopropyl-3-(pyridin-3-ylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1213119

SMILES CC(C)n1c2c(c(n1)C#Cc3cccnc3)c(ncn2)N

InChI Key InChIKey=NYVMTNNWZOHTJT-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50323733   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323733(1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of p110alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323733(1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZ...)
Affinity DataIC50: 664nMAssay Description:Inhibition of p110betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323733(1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZ...)
Affinity DataIC50: 113nMAssay Description:Inhibition of p110gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323733(1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of p110deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323733(1-(1-METHYLETHYL)-3-(PYRIDIN-3-YLETHYNYL)-1H-PYRAZ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)