BDBM50323729 2-((4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one::2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one::CHEMBL1213085

SMILES Cc1ccccc1-n1c(Cn2nc(-c3ccc(O)c(F)c3)c3c(N)ncnc23)nc2cccc(C)c2c1=O

InChI Key InChIKey=TYLTZPAGUBOPCU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50323729   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323729(2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of p110alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323729(2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50: 697nMAssay Description:Inhibition of p110betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323729(2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p110gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323729(2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of p110deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Medical Research Council-Laboratory of Molecular Biology

Curated by ChEMBL
LigandPNGBDBM50323729(2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed