BDBM50323546 4-((E)-styryl)-pyrimidin-2-ylamine::CHEMBL1209431

SMILES Nc1nccc(\C=C\c2ccccc2)n1

InChI Key InChIKey=LNUXNUNUGIHCPA-UHFFFAOYSA-N

Data  2 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50323546   

TargetMetabotropic glutamate receptor 4(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGluR4 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mGluR5 expressed in CHO-K1 cells in absence of glutamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of rat mGluR4 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed