BDBM50323463 CHEMBL1209217::endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl)-3-azabicyclo[3.1.0]hexan-3-yl)(tetrahydrofuran-3-yl)methanone

SMILES O=C(C1CCOC1)N1C[C@H]2[C@@H](CNc3nc(cs3)-c3ccccn3)[C@H]2C1

InChI Key InChIKey=IWNSSSZVCTUKAL-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50323463   

TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323463(endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323463(endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323463(endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323463(endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323463(endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323463(endo-(6-((4-(pyridin-2-yl)thiazol-2-ylamino)methyl...)
Affinity DataKi:  7.94nMAssay Description:Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed