BDBM50323447 2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile::CHEMBL1209704

SMILES Cc1cc2[C@@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C#N

InChI Key InChIKey=PNWAPPMSOGHJLK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50323447   

TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323447(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophe...)
Affinity DataEC50:  196nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323447(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophe...)
Affinity DataIC50: 31nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed