BDBM50323445 2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-methoxypropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile::CHEMBL1209792

SMILES COCC(C)N1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC2(CC1)O[C@@H](c1cc(C)c(Cl)cc21)C(C)(C)C#N

InChI Key InChIKey=DSVBYGCIHQONRH-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323445   

TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323445(2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl...)
Affinity DataEC50:  73nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323445(2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl...)
Affinity DataEC50:  615nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323445(2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl...)
Affinity DataIC50: 44nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed