BDBM50323146 (R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-yl)piperazin-1-yl)(phenyl)methanone::CHEMBL1209454

SMILES C[C@@H]1CN(CCN1c1nnc(-c2ccccc2)c2ccncc12)C(=O)c1ccccc1

InChI Key InChIKey=RPUBLKXADWXFEL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50323146   

TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed