BDBM50323128 (S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone::CHEMBL1209074

SMILES C[C@H]1CN(CCN1c1nnc(-c2ccc(F)cc2)c2ccccc12)C(=O)c1ccccc1

InChI Key InChIKey=MKWOBJMHSUQNJB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323128   

TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323128((S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed