BDBM50322981 CHEMBL1210207::N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)piperidin-4-yl)-5-methylnicotinamide

SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)cc(OCC)c1-c1ccc(F)cc1

InChI Key InChIKey=XQGOSGUJZCQEOJ-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50322981   

TargetSomatostatin receptor type 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataEC50: >1.00E+3nMAssay Description:Antagonist activity at human SST5 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of MK-499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataIC50: 1nMAssay Description:Displacement of (3-125I-Tyr11)-SRIF-28 from mouse SSTR5 expressed in CHO-K1 cell membranes by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at human SSTR5 expressed in CHO-K1 cell membranes assessed as reduction in SST-28-induced inhibition of forskolin-stimulated cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at mouse SSTR5 expressed in CHO-K1 cell membranes assessed as reduction in SST-28-induced inhibition of forskolin-stimulated cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human SSTR1 expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of (3-125I-Tyr11)-SRIF-28 from human SSTR5 expressed in CHO-K1 cell membranes by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322981(N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)...)
Affinity DataKi:  4.40nMAssay Description:Displacement of radio labeled 11 Tyr SST14 from human SST5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed