BDBM50321851 (R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol::CHEMBL1173240::US8796328, D

SMILES Cc1nc(Nc2cccc3CC[C@@H](O)Cc23)oc1-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=CHLCWXNTFXVPAL-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50321851   

LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 180nMAssay Description:The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2]i) using the Fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 180nMAssay Description:The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
Go to US Patent

LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor expressed in human 1321 cells assessed as inhibition of capsaicin-induced in intracellular ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 3.70E+4nMAssay Description:Antagonist activity at rat TRPV2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human TRPV3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human TRPV4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human TRPV1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human TRPV1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 4.40E+4nMAssay Description:Antagonist activity at human TRPM8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed