BDBM50321739 2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile::CHEMBL1172147

SMILES Nc1nc(SCC(=O)c2ccc(Cl)cc2)c(C#N)c(-c2ccsc2)c1C#N

InChI Key InChIKey=IGWMATWUOJUJRZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50321739   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321739(2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321739(2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of human recombinant histidine-tagged ALK (103-1459) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321739(2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human recombinant histidine-tagged ABL (230-517) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed