BDBM50321518 CHEMBL1170367::N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxamide

SMILES CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12

InChI Key InChIKey=CPBGMRFHFZVCLS-UHFFFAOYSA-N

Data  7 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50321518   

TargetAdenosine receptor A2b(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in CHO-K1 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  80nMAssay Description:Binding affinity to adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1 receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50321518(N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed