BDBM50321468 (4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenoxy)pyridin-3-yl)methanone::CHEMBL1170790

SMILES Fc1cccc(Oc2ccc(cn2)C(=O)N2CCCN(CC2)C2CCC2)c1

InChI Key InChIKey=TYYPWLNLMMRCKN-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50321468   

TargetHistamine H3 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321468((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenox...)
Affinity DataKd:  4.17nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321468((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of radiolabeled astemizole from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321468((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenox...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321468((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenox...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321468((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenox...)
Affinity DataKi:  21nMAssay Description:Binding affinity to histamine H3 receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed