BDBM50320362 CHEMBL1082791::phenyl(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)methanone

SMILES O=C(N1CCN(CC1)c1nnc(-c2ccccc2)c2ccccc12)c1ccccc1

InChI Key InChIKey=OEZQQFDHMPRYIY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50320362   

TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320362(phenyl(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)m...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320362(phenyl(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)m...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed