BDBM50319599 (2S)-(4-[3-(4-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ol::CHEMBL1084829

SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccc(F)cc2)S1(=O)=O

InChI Key InChIKey=VUEFLJKLCMGDEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319599   

LigandPNGBDBM50319599((2S)-(4-[3-(4-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)
Affinity DataIC50: 146nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319599((2S)-(4-[3-(4-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)
Affinity DataIC50: 386nMAssay Description:Displacement of [3H]WIN-35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319599((2S)-(4-[3-(4-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)
Affinity DataIC50: 51nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed