BDBM50319572 CHEMBL1084452::N-(4-(3-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine

SMILES CN1CCCC1CCNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12

InChI Key InChIKey=SBSYQSASKXLENU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319572   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(N-(4-(3-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)...)
Affinity DataIC50: 47nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(N-(4-(3-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)...)
Affinity DataIC50: 327nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319572(N-(4-(3-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)...)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(N-(4-(3-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)...)
Affinity DataIC50: 269nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(N-(4-(3-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed