BDBM50319165 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine::3,4-Dimethyl-8-methoxy-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine::CHEMBL1086110

SMILES CCCc1nc(c2n1c3c(ccc(n3)OC)nc2C)C

InChI Key InChIKey=YNADXFWEXJTQSZ-UHFFFAOYSA-N

Data  29 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50319165   

LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of human GST-tagged PDE3A (484 to end residues) using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of human PDE2A using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDE10A2 expressed in HEK293 cells using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.54E+3nMAssay Description:Inhibition of human full-length PDE4D2 expressed in Sf9 insect cells using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 32nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 239nMAssay Description:Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Biotie Therapies

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 919nMAssay Description:Inhibition of PDE5AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 32nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Biotie Therapies

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PDE1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 239nMAssay Description:Inhibition of PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PDE9AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 690nMAssay Description:Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Biotie Therapies

Curated by ChEMBL
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 920nMAssay Description:Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 779nMAssay Description:Inhibition of PDE11AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed