BDBM50318993 1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol::CHEMBL1083995

SMILES COc1ccc(OCC(O)CNC2CCN(CC2)c2ncnc3scc(-c4ccccc4)c23)cc1

InChI Key InChIKey=OTPXFDNEIWKIRR-UHFFFAOYSA-N

Data  5 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50318993   

TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human adrenergic beta3 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataEC50:  120nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataKi:  378nMAssay Description:Displacement of [125I]cyanopindolol from human adrenergic beta3 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataKi:  460nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataKi:  700nMAssay Description:Displacement of [125I]cyanopindolol from human adrenergic beta2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataKi:  700nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50318993(1-(4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]py...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed