BDBM50318963 CHEMBL1084061::rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one

SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1

InChI Key InChIKey=ILSOSVAUZNKTQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50318963   

LigandPNGBDBM50318963(rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318963(rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318963(rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed