BDBM50318947 CHEMBL1085540::rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one

SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCCO)c3ccc(cc23)C2CCCCO2)n1

InChI Key InChIKey=PMUHQDLLPQQYNK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50318947   

LigandPNGBDBM50318947(rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H...)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318947(rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318947(rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed