BDBM50318619 1-Imidazol-1-ylmethylxanthen-9-one::CHEMBL1083652

SMILES O=c1c2ccccc2oc2cccc(Cn3ccnc3)c12

InChI Key InChIKey=FJYGKMHQKKRCON-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50318619   

TargetCytochrome P450 11B2, mitochondrial(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50318619(1-Imidazol-1-ylmethylxanthen-9-one | CHEMBL1083652)
Affinity DataIC50: 114nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50318619(1-Imidazol-1-ylmethylxanthen-9-one | CHEMBL1083652)
Affinity DataIC50: 99nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50318619(1-Imidazol-1-ylmethylxanthen-9-one | CHEMBL1083652)
Affinity DataIC50: 150nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50318619(1-Imidazol-1-ylmethylxanthen-9-one | CHEMBL1083652)
Affinity DataIC50: 880nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50318619(1-Imidazol-1-ylmethylxanthen-9-one | CHEMBL1083652)
Affinity DataIC50: 99nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPTLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50318619(1-Imidazol-1-ylmethylxanthen-9-one | CHEMBL1083652)
Affinity DataIC50: 114nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate after 30 mins by HPTLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed