BDBM50318266 (+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pentanoicAcid

SMILES NC(CCCc1no[nH]c1=O)C(O)=O

InChI Key InChIKey=JYPYAECWCSLQCE-UHFFFAOYSA-N

Data  4 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50318266   

TargetGlutamate receptor 2(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataEC50:  4.91E+5nMAssay Description:Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataIC50: 2.45E+5nMAssay Description:Antagonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as inhibition of (S)-Glu-induced intracellular calcium levels by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataIC50: 2.45E+5nMAssay Description:Antagonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as inhibition of (S)-Glu-induced intracellular calcium levels by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi:  2.00E+4nMAssay Description:Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi:  6.70E+4nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed