BDBM50318235 6-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-9-phenyl-1,3,7-triazaspiro[4.4]nonan-7-yl)pyridazine-3-carboxylic Acid::CHEMBL1096053

SMILES CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1c1ccc(cc1)C#N)c1ccc(nn1)C(O)=O)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=FUVZQLIZJXPMIS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50318235   

TargetIntegrin alpha-L(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50318235(6-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dio...)
Affinity DataIC50: 270nMAssay Description:Inhibition of LFA1-mediated human T cell proliferation assessed as [3H]thymidine uptake after 4 days by mixed lymphocyte reaction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50318235(6-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dio...)
Affinity DataIC50: 13nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed