BDBM50318191 (Z)-3-(5-((7-(3-Fluorophenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]-quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)benzoic Acid::CHEMBL1096755

SMILES OC(=O)c1cccc(c1)-c1ccc(\C=c2/sc3=NC4=C(CCc5ccccc45)C(c4cccc(F)c4)n3c2=O)o1

InChI Key InChIKey=CKYGAKWJAJKWCA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318191   

TargetApoptosis regulator Bcl-2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50318191((Z)-3-(5-((7-(3-Fluorophenyl)-9-oxo-5H-benzo[h]thi...)
Affinity DataIC50: 8.00E+3nMAssay Description:Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50318191((Z)-3-(5-((7-(3-Fluorophenyl)-9-oxo-5H-benzo[h]thi...)
Affinity DataIC50: 1.86E+4nMAssay Description:Displacement of FITC-labeled BH3 peptide from GST-tagged mouse Mcl1 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50318191((Z)-3-(5-((7-(3-Fluorophenyl)-9-oxo-5H-benzo[h]thi...)
Affinity DataIC50: 6.90E+3nMAssay Description:Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50318191((Z)-3-(5-((7-(3-Fluorophenyl)-9-oxo-5H-benzo[h]thi...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human Bcl-XLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed