BDBM50318176 CHEMBL1095131::N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo-[2,3-d]pyrimidine-2,4-diamine

SMILES Nc1nc(Nc2cccc(F)c2)c2cc(Cc3ccc(Cl)cc3Cl)[nH]c2n1

InChI Key InChIKey=QUIDZUWCCTZDCX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318176   

TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318176(N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrr...)
Affinity DataIC50: 300nMAssay Description:Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318176(N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrr...)
Affinity DataIC50: 1.62E+5nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318176(N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrr...)
Affinity DataIC50: 1.63E+5nMAssay Description:Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318176(N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrr...)
Affinity DataIC50: 1.83E+5nMAssay Description:Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed