BDBM50318100 8-(Phenylamino)-1-(propan-2-yl)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide::CHEMBL1094735

SMILES CC(C)n1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12

InChI Key InChIKey=OQCYIOKKFGCDSR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50318100   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318100(8-(Phenylamino)-1-(propan-2-yl)-4,5-dihydro-1H-pyr...)
Affinity DataIC50: 46nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318100(8-(Phenylamino)-1-(propan-2-yl)-4,5-dihydro-1H-pyr...)
Affinity DataIC50: 430nMAssay Description:Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318100(8-(Phenylamino)-1-(propan-2-yl)-4,5-dihydro-1H-pyr...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed