BDBM50317574 1-(2-(5-Hydroxy-1H-indol-2-yl)ethyl)-3-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]urea::CHEMBL1098225

SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1NC(=O)NCCc1cc2cc(O)ccc2[nH]1

InChI Key InChIKey=LYSKZSZXKTWRSM-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50317574   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317574(1-(2-(5-Hydroxy-1H-indol-2-yl)ethyl)-3-[(1R,2S,5R)...)
Affinity DataEC50:  5.22E+4nMAssay Description:Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as intracellular calcium stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317574(1-(2-(5-Hydroxy-1H-indol-2-yl)ethyl)-3-[(1R,2S,5R)...)
Affinity DataIC50: 1.58E+4nMAssay Description:Antagonist activity at rat TRMP8 receptor expressed in HEK293 cells assessed as menthol-induced calcium elevationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317574(1-(2-(5-Hydroxy-1H-indol-2-yl)ethyl)-3-[(1R,2S,5R)...)
Affinity DataIC50: 3.10E+4nMAssay Description:Antagonist activity at rat TRMP8 receptor expressed in HEK293 cells assessed as menthol-induced calcium elevationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed