BDBM50317558 CHEMBL1094770::N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphenyl-4-carboxamide

SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1NC(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=IGJNFEGERSIBAW-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50317558   

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat TRMP8 receptor expressed in HEK293 cells assessed as menthol-induced calcium elevationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as intracellular calcium stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at rat TRMP8 receptor expressed in HEK293 cells assessed as menthol-induced calcium elevationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 805nMAssay Description:Antagonist activity at recombinant human TRPM8 stably expressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 1.80E+3nMAssay Description:Antagonist activity at recombinant human TRPM8 stably expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium level ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 117nMAssay Description:Antagonist activity at recombinant rat TRPM8 stably expressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium level b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 521nMAssay Description:Antagonist activity at recombinant rat TRPM8 stably expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium level by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at recombinant human TRPM8 transiently expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux by whole-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed