BDBM50316619 (+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl]-2-(3,4-dichlorophenyl)ethanone::CHEMBL1095521

SMILES Clc1ccc(CC(=O)N2C[C@H]3CC[C@H]([C@@H]2CN3Cc2ccccc2)N2CCCC2)cc1Cl

InChI Key

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50316619   

TargetKappa-type opioid receptor(Human)
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316619((+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8...)
Affinity DataEC50:  820nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding after 45 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316619((+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane after 150 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316619((+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8...)
Affinity DataKi:  70nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding after 45 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316619((+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8...)
Affinity DataKi:  470nMAssay Description:Displacement of [(3)H]U69593 from mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316619((+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]deltorphine-2 from human delta opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316619((+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed