BDBM50316379 1,1'-(1,3,7,9-Tetrahydroxydibenzofuran-2,6-diyl)bis(2-methylbutan-1-one)::CHEMBL1097227::US9273021, 4

SMILES CCC(C)C(=O)c1c(O)cc2oc3c(C(=O)C(C)CC)c(O)cc(O)c3c2c1O

InChI Key InChIKey=FOVPRACMJLBLEN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50316379   

TargetFructose-1,6-bisphosphatase 1(Pig)
Boston College

US Patent
LigandPNGBDBM50316379(US9273021, 4 | 1,1'-(1,3,7,9-Tetrahydroxydibenzofu...)
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:FBPase activity was measured spectrophotometrically by employing the coupling enzymes phosphoglucose isomerase and glucose-6-phosphate dehydrogenase....More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetFructose-1,6-bisphosphatase 1(Human)
Boston College

US Patent
LigandPNGBDBM50316379(US9273021, 4 | 1,1'-(1,3,7,9-Tetrahydroxydibenzofu...)
Affinity DataIC50: 6.00E+3nMpH: 7.5Assay Description:FBPase activity was measured spectrophotometrically by employing the coupling enzymes phosphoglucose isomerase and glucose-6-phosphate dehydrogenase....More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetFructose-1,6-bisphosphatase 1(Human)
Boston College

US Patent
LigandPNGBDBM50316379(US9273021, 4 | 1,1'-(1,3,7,9-Tetrahydroxydibenzofu...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Pig)
Boston College

US Patent
LigandPNGBDBM50316379(US9273021, 4 | 1,1'-(1,3,7,9-Tetrahydroxydibenzofu...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Boston College

US Patent
LigandPNGBDBM50316379(US9273021, 4 | 1,1'-(1,3,7,9-Tetrahydroxydibenzofu...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human liver FBPase by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed